Childhood-onset growth hormone deficiency is a condition where the pituitary gland fails to produce enough growth hormone during childhood. With early diagnosis and treatment, children generally achieve relatively normal height and development.
Corticotrophin-releasing hormone is the main element that drives the body's response to stress. It is also present in diseases that cause inflammation. Too much or too little corticotrophin-releasing hormone can have a range of negative effects.
Circadian rhythm sleep disorders occur when the circadian clock in the brain, which drives daily behavioural and physiological rhythms, is not synchronised with 'real' local time. This can result in abnormal sleep patterns, sleep loss and fatigue.
Congenital adrenal hyperplasia is an inherited disorder that results in low levels of cortisol and high levels of male hormones, causing development of male characteristics in females, and early puberty in both boys and girls.
(CBT) a specific type of talking therapy where a therapist helps the patient to look at connections between their thoughts, feelings, symptoms and behaviour.
a procedure carried out during early pregnancy to obtain tissue from the placenta for genetic testing. The process comes with a slightly increased risk of miscarriage.
Chronic fatigue syndrome is a condition that causes long-term and energy-draining tiredness, which does not improve with rest or sleep.
condition affecting the heart that is present at birth.
a surgical procedure, performed alongside removal of the thyroid gland, where surrounding lymph nodes are surgically removed along with the thyroid gland.
(CT) a type of scan used to create detailed images of the inside of the body. It involves X-rays and a computer. Also known as a CAT scan or computed tomography.
numbness, ‘pins and needles’ and pain in the hands and wrist, particularly around the thumb; caused by pressure on the median nerve in the wrist.
consists of two major structures: the brain and spinal cord.
Cushing's syndrome is the name given to the collection of signs and symptoms that occur when the body is exposed to too much of the hormone cortisol.
a hormone drug taken by women to prevent ovulation and therefore to stop a pregnancy occurring (contraception). There are several different types of pill; the ‘combined’ pill contains oestrogen and progesterone; the ‘mini’ pill contains progesterone-only.
Craniopharyngiomas are rare slow-growing benign brain tumours, which most commonly occur above the pituitary gland, but occasionally are found within the bony cup containing the pituitary gland.
Cushing's disease is the collection of clinical symptoms and signs resulting from a pituitary tumour that causes excessive amounts of the hormone cortisol to be released by the adrenal glands.
a type of tissue made from collagen and fatty cells within a jelly-like lattice. Connective tissue functions to support organs, fill the spaces between organs, and form tendons and ligaments.
Carcinoid tumours are slow-growing tumours that arise from specialised cells that release hormones.
Cholecystokinin is a gut hormone released after a meal, which helps digestion and reduces appetite.
hormones secreted from the cortex of the adrenal gland that include glucocorticoids (e.g. cortisol), mineralocorticoids (e.g. aldosterone) and androgens (e.g. testosterone).
a chronic condition in which tissues become inflamed; particularly affects the walls of the small intestine, causing strong pains, constipation and vomiting.
a glucocorticoid hormone produced by the adrenal glands. Cortisol is the main glucocorticoid in most animal species but corticosterone is higher in animals such as amphibians, rodents, reptiles and birds.
a temporary endocrine gland formed from the ruptured ovarian follicle (which enclosed the egg) after an egg is released at ovulation. The corpus luteum produces the hormones progesterone and oestradiol (an oestrogen).
a calcium salt used to ‘mop up’ excess calcium in the bloodstream.
a drug that blocks the production of thyroid hormones; used in the treatment of hyperthyroidism to reduce thyroxine levels.
Calcitonin is a hormone that is produced and released by the C-cells of the thyroid gland. Its biological function in humans is to have a relatively minor role in calcium balance.
the point at which a sperm successfully fertilises an egg and an embryo is formed.
describes a condition that is present at birth.
opacity in the lens of the eye leading to impaired vision or blindness. Cataracts are more frequent in the elderly and in people with diabetes.
Cortisol is a steroid hormone that regulates a wide range of processes throughout the body, including metabolism and the immune response. It also has a very important role in helping the body respond to stress.
describes a condition that is long term or one that progresses slowly. Examples of chronic conditions are asthma, eczema and type 1 diabetes mellitus.
the neck or opening of the womb. During labour the cervix opens to allow the foetus to be delivered.